Oncolytic Virus Therapy for Glioblastoma Multiforme
نویسندگان
چکیده
منابع مشابه
Radiothermotherapy for glioblastoma multiforme: A preliminary study
Introduction: Glioblastoma multiforme (GBM) is a highly radioresistant cancer with low survival rate. Current therapy approaches have failed to treat GBM. The aim of this study was to assess how GBM tumors respond to combination of hyperthermia and radiotherapy. Materials and Methods: In this study, 38 GBM patients were included. 19 patients were treated ...
متن کاملTargeted therapy for glioblastoma multiforme neoplastic meningitis with intrathecal delivery of an oncolytic recombinant poliovirus.
PURPOSE The toxicity and antitumor activity of regional intrathecal delivery of an oncolytic recombinant poliovirus, PVS-RIPO, was evaluated in rodent models of glioblastoma multiforme neoplastic meningitis. EXPERIMENTAL DESIGN To evaluate for toxicity, PVS-RIPO was administered into the spinal cord of transgenic mice that express the human poliovirus receptor, CD155, and into the intrathecal...
متن کاملViral therapy of glioblastoma multiforme.
Of all human malignancies, glioblastoma multiforme (GBM) is among the most refractory to existing therapies despite combination approaches of surgical resection, irradiation, and chemotherapy. The median survival is ∼12–14 mo, regardless of the therapeutic intervention. The 5-y survival of patients with a diagnosis of GBM is less than 9.8% (1). This remarkably poor rate of survival begs the que...
متن کاملGlioblastoma Multiforme Therapy and Mechanisms of Resistance
Glioblastoma multiforme (GBM) is a grade IV brain tumor characterized by a heterogeneous population of cells that are highly infiltrative, angiogenic and resistant to chemotherapy. The current standard of care, comprised of surgical resection followed by radiation and the chemotherapeutic agent temozolomide, only provides patients with a 12-14 month survival period post-diagnosis. Long-term sur...
متن کاملGlioblastoma multiforme targeted therapy: The Chlorotoxin story.
Glioblastoma multiforme (GBM) is the most common malignant primary brain neoplasm having a mean survival of <24months. Scorpion toxins are considered promising cancer drug candidates, primarily due to the discovery of hlorotoxin, derived from the venom of the Israeli yellow scorpion. This intriguing short peptide of only 36 amino-acids length and tight configuration, possess the ability to bind...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Cancer Journal
سال: 2012
ISSN: 1528-9117
DOI: 10.1097/ppo.0b013e31824671c9